ng/mL
Plasma concentrations of rivaroxaban following
once daily dosing were as follows (12):
Mean Range (+/- 2SD)
10 mg (Once Daily) Dose:
Peak 124.6 91.4 - 195.5
Trough 9.1 1.3 - 37.6
20 mg (Once Daily) Dose:
Peak 222.6 159.6 - 359.8
Trough 22.3 4.3 - 95.7
Peak levels should be drawn 3 hours
after oral dosing.
Trough levels are drawn 24 hours
after oral dosing.
Steady state is attained after 4 to 6 days of once
daily treatment. The
peak and trough ranges
were obtained from the following study and represent the
median (5th and 95th percentiles). The 10 mg dose study
included 135 patients and the 20 mg dose study 131 patients.
Mueck W, Borris LC, Dahl OE et al. Population
pharmacokinetics and pharmacodynamics of once- and
twice-daily rivaroxaban for the prevention of venous
thromboembolism in patients undergoing total hip
replacement. Thromb Haemost. 2008 Sep;100(3):453-461.
This test was developed and its performance characteristics
determined by Labcorp. It has not been cleared or
approved by the Food and Drug Administration.