Neurology

ATN Profile

Sample Type: Plasma (frozen)

This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer’s disease pathology.

APOE Alzheimer’s disease Risk

Sample Type: Buccal Swab (Dynacare Kit)

This test detects the presence of the Apolipoprotein E (APOE)-4 variant, which is associated with increased risk of late-onset (age >60-65) Alzheimer’s disease (AD). Testing may be considered for patients with dementia to supplement information from clinical and other evaluations.

Phosphorylated Tau 217 (pTau-217)

Sample Type: Plasma

An aid in the identification of Alzheimer’s disease pathology by detecting the presence or absence of pTau-217, which has been shown in the literature to be a surrogate of amyloid pathology. Additionally, pTau-217 can be used for monitoring patients on newly approved anti-amyloid therapies.

Beta Amyloid 42/40 Ratio

Sample Type: Plasma (frozen) and CSF

Our Beta-Amyloid 42/40 Ratio test quantifies the amount of beta-amyloid 42 and 40 proteins in a plasma patient sample and computes the ratio of those proteins, providing an indication of amyloid pathology for Alzheimer’s disease.

Glial Fibrillary Protein (GFAP)

Sample Type: Plasma

AD is a complex and heterogeneous disease, influenced by many genetic and environmental factors. Early onset familial AD (presenting between 25-60) occurs in less than 2% of AD cases.

Neurofilament Light Chain (NfL)

Sample Type: Serum

NfL, in the context of Alzheimer’s disease, provides an indication of disease severity by measuring the current level of neurodegeneration.

Phosphorylated Tau 181 (pTau-181)

Sample Type: Plasma

This test detects and quantifies pTau-181 proteins in plasma, which has been demonstrated to be predictive in differentiating Alzheimer’s from other dementias.

Early Onset Alzheimer’s NGS Diagnostic Test

Sample Type: Whole blood (EDTA)

AD is complex and heterogeneous disease, influenced by many genetic and environmental factors. Early onset familial AD (presenting between 25-60) occurs in less than 2% of AD cases.

Neurofilament Light Chain (NfL) Test

Sample Type: Serum

NfL is a well-studied blood biomarker test that is now widely available through Dynacare for assessing neuronal damage from neurodegenerative diseases and sports-related concussion.