Neurology

ATN Profile

Sample Type: Plasma (frozen)

This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer’s disease pathology.

APOE Alzheimer’s disease Risk

Sample Type: Buccal Swab (Dynacare Kit)

This test detects the presence of the Apolipoprotein E (APOE)-4 variant, which is associated with increased risk of late-onset (age >60-65) Alzheimer’s disease (AD). Testing may be considered for patients with dementia to supplement information from clinical and other evaluations.

PTBA pTau-217/Beta Amyloid 42

Sample Type: Plasma

In the context of all clinical findings in individuals presenting with cognitive impairment, the pTau-217/Beta Amyloid 42 Ratio can aid in the identification of amyloid-related pathology, which is associated with Alzheimer’s disease. This test is not intended as a screening test for Alzheimer’s disease in asymptomatic individuals.

Phosphorylated Tau 217 (pTau-217)

Sample Type: Plasma

An aid in the identification of Alzheimer’s disease pathology by detecting the presence or absence of pTau-217, which has been shown in the literature to be a surrogate of amyloid pathology. Additionally, pTau-217 can be used for monitoring patients on newly approved anti-amyloid therapies.

Beta Amyloid 42/40 Ratio

Sample Type: Plasma (frozen) and CSF

Our Beta-Amyloid 42/40 Ratio test quantifies the amount of beta-amyloid 42 and 40 proteins in a plasma patient sample and computes the ratio of those proteins, providing an indication of amyloid pathology for Alzheimer’s disease.

Glial Fibrillary Protein (GFAP)

Sample Type: Plasma

GFAP is a protein expressed mostly in astrocytes in the brain. In conjunction with markers of amyloid pathology, GFAP has been shown to be a predictor of Alzheimer’s disease.

Neurofilament Light Chain (NfL)

Sample Type: Serum

NfL is a well-studied blood biomarker test that assesses disease severity (level of neuronal damage) from neurodegenerative diseases, like Alzheimer’s, and sports-related concussion.

Phosphorylated Tau 181 (pTau-181)

Sample Type: Plasma

This test detects and quantifies pTau-181 proteins in plasma, which has been demonstrated to be predictive in differentiating Alzheimer’s from other dementias.

Early Onset Alzheimer’s NGS Diagnostic Test

Sample Type: Whole blood (EDTA)

Early onset familial AD (presenting between ages 25-60) occurs in less than 2% of AD cases. This test analyzes three genes (amyloid protein precursor (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2)) to detect pathogenic variants that cause autosomal dominant early onset Alzheimer's disease.