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Mental Health Solutions

Genecept Assay®: Find the right treatment faster

Finding the right treatment takes time

Despite the availability of effective treatments for many psychiatric illnesses, including mood and anxiety disorders, arriving at the best treatment can still take weeks or months. Patients can become discouraged, discontinue treatments and experience prolonged suffering.

An estimated two-thirds of patients with depression will not respond to first-line treatment, and more than one-third will become treatment-resistant.1-3

The Genecept Assay can shorten the path to finding effective treatments

The Genecept Assay is a genetic test designed to help clinicians optimize treatment decisions and choose medications more likely to be safe and effective.

  • Identifies variations in 18 key genes relevant to psychiatric treatment that indicate which therapies are likely to work as intended and not result in unwanted side effects or adverse events
  • Easily administered as a cheek swab test
  • Every result report includes a complimentary individualized consultation with an expert

The Genecept Assay covers a wide range of psychiatric disorders

Candidates for testing include:

  • Patients living with:
    • Depression
    • Anxiety
    • Obsessive-compulsive disorder (OCD)
    • Attention deficit hyperactivity disorder (ADHD)
    • Bipolar disorder
    • Post-traumatic stress disorder (PTSD)
    • Autism spectrum disorder
    • Schizophrenia
    • Chronic pain
    • Substance abuse
  • Any patient without optimal treatment response: previously failed treatment trials, poor response or adverse events
  • Patients with polypharmacy
  • Patients with psychiatric and medical comorbidities
  • Patients with medication adherence issues

The Genecept Assay reports are easy to read, understand and share

Three types of test results are possible:

  • A positive or clinically significant gene result
  • A negative or non-clinically significant gene result (normal)
  • An indeterminate gene result (may trigger a retest), or a gene variation of uncertain clinical significance – this result type is rare

The Genecept Assay report walks you through the genetic results and their treatment implications in detail. The report is easy to explain to patients, and the results help you have productive consultations about treatment with patients and families to improve adherence.

Clinical trial results

Studies have shown that using the Genecept Assay has resulted in significant improvements in clinical and economic outcomes.

Measurable clinical improvement, physician-reported4

In a naturalistic study of 685 patients, clinician-rated data using the Clinician Global Impression Improvement scale (CGI-I) showed that:

  • 87% of patients demonstrated a clinically measurable improvement
  • 62% of patients showed a significant clinical improvement (rated much improved or very much improved)
  • Of the 69% of patients reported as treatment resistant, 91% demonstrated a clinically measurable improvement

Measurable patient improvement, patient-reported4

In the same study, patients reported significant:

  • Decreases in depression
  • Decreases in anxiety
  • Decreases in medication side effects
  • Increases in quality of life

Improved patient adherence5

In a retrospective analysis of health claims data, individuals with Genecept Assay-guided treatment were significantly more medication adherent (a 6% increase) than patients with standard treatment.

An expanded panel for greater insight

The Genecept Assay includes:

  • 18 well-characterized, well-annotated genes, extensively supported in peer-reviewed publications to affect treatment for psychiatric conditions
  • A report with more than 195 citations to the literature
  • 12 pharmacodynamic genes, 6 pharmacokinetic genes

The Genecept Assay analyzes two types of genes to inform proper treatment:

  • Pharmacodynamic genes indicate the effect a drug has on the body and inform drug candidate selection.
  • Pharmacokinetic genes indicate the effect the body has on the drug via metabolism and inform drug dosage.
Chart listing different genes and potential associated risks

Results in 5 to 8 business days from sample receipt

Ordering the Genecept Assay is simple:

  1. Use the supplied collection kit to obtain a cheek (buccal) swab specimen from your patient.
  2. Your patient’s specimen will be tested upon receipt of the sample at our laboratory, and you will receive a results report within 5 to 8 business days from sample receipt.

Complimentary consultation service

With each Genecept Assay report, Dynacare includes an optional and complimentary expert consultation service, enabling you to consult with a physician or pharmacist to help determine optimal treatment. To schedule a consultation, call 888.988.1888.

To learn more about the Genecept Assay, contact us at 888.988.1888 or

Access our Genecept Assay patient brochure
Access our Genecept Assay physician brochure
Access our Genecept Assay White Paper
Access our Genecept Assay Sample Report
Access our Genecept Assay forms

1. Souery D, Papakostas GI, Trivedi MH. Treatment-resistant depression. J Clin Psychiatry. 2006;67(suppl 6):16–22.
2. Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: Results from the national comorbidity survey replication (ncs-r). JAMA. 2003;289(23):3095–3105.
3. Warden D, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. The STAR*D project results: A comprehensive review of findings. Curr Psychiatry Rep. 2007;9:449–459.
4. Brennan FX et al. A naturalistic study of the effectiveness of pharmacogenetics testing to guide treatment in psychiatric patients with mood and anxiety disorders. Prim Care Companion CNS Disord. 2015;17(2).
5. Fagerness J et al. Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings. Am J Manag Care. 2014;20(5):e146–e156.