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Hemoglobinopathy Screening Program

Dynacare has created a pathway for comprehensive hemoglobinopathy screening including molecular testing and genetic counselling for the province of Ontario.

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Why Screen For Hemoglobinopathies?

Hemoglobinopathies and thalassemias are some of the most common single gene disorders in humans. These conditions are more common in certain ethnic groups, such as Asian, Mediterranean, African, Middle Eastern, Caribbean and South/Central American.

Approximately 5.2.% of the world’s population carries a significant hemoglobin variant1

At least 20% of the world’s population carries an alpha+ thalassemia variant1

Approximately 1 in 4 Ontarians identify as one of these ethnic groups2 and therefore may be at risk of having a child with a clinically significant blood disorder

For a breakdown of carrier frequencies by region, click here.

View References

Steps for Hemoglobinopathy Testing

 

Tests Included

CBC, quantitative hemoglobin (Hb) electrophoresis or HPLC and serum ferritin

  1. Order Screening

    1. Fill-out the Dynacare pre-completed requisition.

      Download Requisition
    2. Upload the completed requisition to the Dynacare Requisition Uploader, our secure test ordering portal.

      Upload Requisition
  2. Provide Sample

    Patients will have up to 6 months to go to a Dynacare location. Patients can check in remotely by using the free Dynacare Net CheckIn app available in Google Play or the Apple App Store.

  3. Access Result

    Result will be available in 1-4 business days.

    Proceed to molecular testing if the general screening results are indicative of a possible hemoglobinopathy (see ranges below).

Results Indicating a Possible Hemoglobinopathy

MCV < 80fL or MCH < 27pg AND normal Hb Electrophoresis/HPLC

MCV < 80fL and/or MCH < 27pg AND increased Hb A2 or F via Electrophoresis/HPLC

Hb variant via Electrophoresis/HPLC (e.g. HbS, HbC, HbD, HbE)

Steps for Hemoglobinopathy Testing

 
  1. Order Molecular Testing

    1. Complete the Hamilton molecular requisition.

      Download Requisition
    2. Upload the completed requisition to the Dynacare Requisition Uploader, our secure test ordering portal along with copies of CBC, quantitative hemoglobin (Hb) electrophoresis or HPLC and serum ferritin.

      Upload Requisition
  2. Provide Sample

    Patients will have up to 6 months to go to a Dynacare location. Patients can check in remotely by using the free Dynacare Net CheckIn app available in Google Play or the Apple App Store.

  3. Access Result

    Results will be available in 6 to 8 weeks if the patient is pregnant and up to 1 year if the patient is not pregnant.

    Patients with a positive molecular test result should be offered genetic counselling.

Steps for Hemoglobinopathy Testing

 

How to Refer

  1. Via Fax

    1. Complete the Dynacare Hemoglobinopathy Genetic Counselling Referal Form.

      Download Requisition
    2. Fax the completed form to 450.901.3076 along with the following documents: CBC, quantitative hemoglobin (Hb) electrophoresis or HPLC, serum ferritin and molecular test results.

  2. Via Dynacare Consult

    1. Complete the required fields on the Dynacare Consult platform, which serves as the online referral form for genetic counselling.

      Dynacare Consult
    2. Upload the following documents: CBC, quantitative hemoglobin (Hb) electrophoresis or HPLC, serum ferritin and molecular test results.

    3. Please include the patient’s email address and mobile number. An email/text will be sent to them to create a profile to complete a family history questionnaire.

    4. Select an appropriate timeslot for your patient to have their genetic counselling consult.

Please note what language your patient prefers/is able to communicate in. For languages other than English or French, arrangements will be made to collect the family/ medical history verbally with the use of a medical translator rather than via an online questionnaire.

Other Genetic Tests We Offer

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Harmony test for NIPT testing

Harmony test for NIPT testing

As the only non-invasive prenatal test approved by Health Canada, the Harmony test from Dynacare Prenatal Solutions provides accurate screening for Trisomy 21 (Down syndrome), Trisomy 18 and 13, and sex chromosome abnormalities.

Color Test for Hereditary Cancer Screening

Color Test for Hereditary Cancer Screening

Color analyzes 30 genes – including BRCA1 and BRCA2 – to help women and men understand their risk for the most common hereditary cancers, including breast, ovarian, colorectal, pancreatic and other cancers.

Benefits and Features for your Patients

Dynacare Plus

Dynacare Plus

We help patients understand and manage their health information with Dynacare Plus. Patients get their test results conveniently online.

Find a Location

Find a Location

Patients can find the nearest location for specialty or general diagnostic tests.

Preparation and Tips

Preparation and Tips

We put together some handy tips to help patients to better prepare before coming to Dynacare.