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JOINTstat

Test Details
Test Name : JOINTstat
Alternative Test Names : JOINTstat, 14-3-3, 14-3-3(eta)
Code: JNTS
Test Overview : JOINTstat is a blood test used to diagnose rheumatoid arthritis (RA). The test measures a protein in the blood, known as 14-3-3(eta) that is involved in biochemical pathways that lead to inflammation and joint degradation.
Test Preparation Instructions : N/A
Turnaround Time: 12 DAYS
Reference Interval:
Age Reference Interval
Sex Low High Component Low High Units Note
M/F < 0.19
Age
Sex Low High Component
M/F

Reference Interval
Low High Units Note
< 0.19
(1)

Negative : < 0.19 ng/mL
Positive: >= 0.19 ng/mL
Serum 14-3-3n protein is a highly sensitive and specific
rheumatoid arthritis (RA) biomarker and is recommended
for monitoring clinical response to treatment as well as the
risk of radiographic progression.
Serum 14-3-3n protein is elevated in both
established RA (sensitivity 77%) and early RA (sensitivity
59-64%)1,2. When serum 14-3-3n protein is used together
with rheumatoid factor (RA factor or RF) and
anti-citrulinated peptide antibodies (anti-CCP or CCP
anitbodies), the three markers can diagnose established RA
with a sensitivity of 88-96% and early RA with a sensitivity
of 88-96% and early RA with a sensitivity of 78-92%1,2.
An increased level of one or more of these markers is
consistent with a diagnosis of RA. When all three markers
are negative, an RA diagnosis is less likely.
References:
1. Maksymowych WP et al. J Rheumatol 2015;42(9):1587-1594.
2. Maksymowych WP et al. J Rheumatol 2014;41(11):1-10.
Carrier N, et al. Serum levels of 14-3-3n protein
supplement C-reactive protein and rheumatoid
arthritis-associated antibodies to predict clinical
and radiographic outcomes in a prospective
cohort of patients with recent-onset inflammatory
polyarthritis. Arthritis Res Ther 2016;18:37
Maksymowych WP, et al. 14-3-3n is a novel mediator
associated with the pathogenesis of rheumatoid
arthritis and joint damage.
Arthritis Res Ther. 2014;16:R99

Specimen Requirements
Specimen Type: Serum
Container: SGT
Volume: 1.00mL

Collection Requirements: Specimen may be collected in Dr's office and submitted as per routine samples but must arrive at Dynacare laboratory within 72 hours of collection. Samples will be frozen upon receipt in a Dynacare main lab facility. Centrifuge. Separate serum from cells. Aliquot serum to a transport tube.
Storage and Transport: If specimen will be received at a Dynacare main lab location within 72 hours of collection, store and ship refrigerated. If not, store frozen and ship on dry ice.

OptimalRx Plus®

Formerly known as Genecept Assay®
New name. Same trusted results.