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Exclusively Available through Dynacare

ATN Profile
AMYLOID-TAU-NEURODEGENERATION

The first simple, objective blood test to identify Alzheimer’s disease

Intended for clinicians of patients undergoing a dementia workup, this test can help shorten the time to diagnose Alzheimer’s disease.

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What is ATN?

The ATN framework establishes a means for classifying biomarkers based on the biological evidence of Alzheimer’s disease that each marker provides1. These markers are divided into three categories to reflect the three primary biological changes associated with Alzheimer’s:

Amyloid Plaques
Amyloid Plaques

Accumulations of beta- amyloid 42 proteins begin to form plaques in the brain years before initial symptom onset.

Tau Tangles
Tau Tangles

The beta-amyloid 42 accumulation causes misfolding of tau proteins, which tangle into knots and disrupt normal brain cell function.

Assess levels of pathologic change
consistent with Alzheimer’s disease

Neurodegeneration
Neurodegeneration

Brain cell functional impairment causes the cells to die, which exacerbates the characteristic cognitive impairment symptoms observed in Alzheimer’s patients.

Assess disease severity by measuring neurodegeneration

About the Test

ATN Profile Test Alzheimer’s Disease Diagnosis Test Accuracy
ATN Profile Test

This is the first Alzheimer’s blood test that combines three Alzheimer’s biomarkers that is simple, non-invasive and gives objective evidence for the biological changes associated with Alzheimer’s disease. The test is intended to be used by clinicians for patients that may be undergoing a dementia workup.

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Alzheimer’s Disease Diagnosis

Biological confirmation of disease is necessary for diagnosis. This test provides evidence of the biological changes that are consistent with Alzheimer’s disease. However, Alzheimer’s still requires a clinical diagnosis based on clinical observation and cognitive testing. Overall, the ATN framework for blood-based biomarkers can complement imaging and CSF analysis and create an opportunity for a more effective patient journey, and help accelerate the path to Alzheimer’s diagnosis.

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Test Accuracy

The ATN Profile was clinically validated using 200 samples from a well-studied cohort in which all samples were characterized with patient age, sex, amyloid PET status, and clinical diagnosis. The beta-amyloid 42/40 ratio assay showed a ROC analysis area under the curve (AUC) of 0.944, with a sensitivity of 96% and specificity of 86.7%.

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We Can Help You Meet your Neurology Needs

Contact a Dynacare representative to learn how the ATN Panel can help you accelerate the path to Alzheimer’s diagnosis.

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A Comprehensive Suite of Integrated
Diagnostic Testing Services

From scientists, customer service, information technology, specimen collection and transport teams, to quality testing, we combine all in one, offering you:

  • An extensive network of managed care plans
  • Patient service centers for specimen collection
  • Courier services for in-office specimen pickup
  • Genetic counsellors for result interpretation
  • Specialty customer service representatives to assist with test inquiries, add-on testing, or other account service needs